< BackResearch FacultyMark Humayun, MD, PhD

Mark Humayun, MD, PhD

Division: neural-electronics, neural-scaffolds, neurophotonics, neurorx

University Professor; Professor of Ophthalmology, Biomedical Engineering, and Integrative Anatomical Sciences; Cornelius J. Pings Chair in Biomedical Sciences; Co-Director, USC Eye Institute; Director of USC Institute for Biomedical Therpeutics; Director, USC Sensory Science Institute

Research Interests:

As director of the USC Institute for Biomedical Therapeutics, Dr. Humayun and his team are leading the investigation and development of novel neural platforms to diagnose and treat patients with debilitating neurological conditions. Major research applications include developing the next generation of Argus II, the world’s first FDA approved artificial retinal prosthesis for patients suffering from an inherited form of retinitis pigmentosa (RP).  As principal investigators, Drs. Humayun and David Hinton, received $19 M funding from CIRM (California Institute for Regenerative Medicine) to lead a stem cell initiative. The research team has developed a unique procedure by which a scaffold of stem-cell derived retinal pigment epithelium cells may be surgically implanted into the back of the eye, replacing diseased tissue to treat those suffering from Age-related Macular Degeneration (AMD).


Mark Humayun, MD, PhD, is the Cornelius J. Pings Chair in Biomedical Sciences, Professor of Ophthalmology, Biomedical Engineering and Cell and Neurobiology, Director of the USC Institute for Biomedical Therapeutics, and Co-Director of the USC Roski Eye Institute. As the director of USC IBT, Dr. Humayun’s vision is to create an interdisciplinary environment of research and discovery. At the intersection of engineering and medicine, his research projects focus on the treatment of the most debilitating and challenging neurological diseases through advanced engineering. Dr. Humayun earned his BS at Georgetown University, his MD and residency at Duke University Medical School, his Ph.D. in Biomedical Engineering at the University of North Carolina, and his advanced fellowship training in retinal surgery from Johns Hopkins. Dr. Humayun is the co-inventor of Argus II, which offers functional sight to those with complete retinal blindness. He was elected to the prestigious National Academy of Medicine (NAM) and National Academy of Engineering (NAE) for his pioneering work to restore sight. In addition, amongst the many other awards and recognitions, Dr. Humayun was named Inventor of the Year by R&D magazine (2005) and top 1 % of ophthalmologists in U.S. News & World Report.

List of Publications:

  • Weiland JD, Humayun MS. Retinal prosthesis. IEEE Trans Biomed Eng. 2014 May;61(5):1412-24. doi: 10.1109/TBME.2014.2314733.
  • Stefanini FR, Maia M, Falabella P, Pfister M, Niemeyer M, Kashani AH, Humayun MS, Koss MJ. Profile of ocriplasmin and its potential in the treatment of vitreomacular adhesion. Clin Ophthalmol. 2014 May 6;8:847-56. doi: 10.2147/OPTH.S32274.
  • Kashani AH, Lopez Jaime GR, Saati S, Martin G, Varma R, Humayun MS. Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects: a study using hyperspectral computed tomographic imaging spectroscopy.Retina. 2014 Sep;34(9):1854-60. doi: 10.1097
  • Pfister M, Lue JC, Stefanini FR, Falabella P, Dustin L, Koss MJ, Humayun MS. Comparison of reaction response time between hand and foot controlled devices in simulated microsurgical testing. Biomed Res Int. 2014;2014:769296. doi: 10.1155/2014/769296.


  • MD, Duke University Medical School 1989
  • PhD, University of North Carolina 1994
  • Internship, Roanoke Memorial Hospital, 1990
  • Residency, Duke Eye Center, 1990 – 1993
  • Fellowhsip,Wilmer Eye Institute at Johns Hopkins 1994 – 1995

Other web profiles: