Translational Research In Vivo Core Facility

Welcome to the Translational Research In Vivo Core Facility, a center dedicated to live-animal research. The facility is located in the DVRC vivarium, an AAALAC-accredited space containing equipment specialized for both small and large animal eye research. The vivarium has more than 12,000 sq. ft. and includes dedicated animal procedure rooms. Two full-time animal technicians are available to assist researchers with surgical procedures and equipment operation. A third technician is available to process animal tissue for histological analysis postmortem. The Core is managed under the direction of Mark Humayun, MD, PhD and Debbie Mitra, PhD.

Our Vision

As we strive to develop treatments to meet the unmet medical needs of our patients, translational research is essential to turning ideas from the bench top into reality. The Translational In Vivo Core Facility, a center dedicated to live-animal research, is critical to enabling this vision especially as it pertains to medical devices. The Translational In Vivo Core Facility gives investigators access to technicians and a wide-range of instrumentation.  We are dedicated to providing state-of the Art equipment and services that would help advance translational research initiatives.

 

Vivarium Services

Translational Research In Vivo Core Services Active Price*
Rodent Anesthesia $10
Rodent Topical Medications $35
Rodent Imaging/Laser $35
Rodent Post-Op Care $10
Rabbit Anesthesia $10
Rabbit Imgaing/Laser $60
Rabbit Vitrectomy $615
Dog Anesthesia $15
Pig Anesthesia $20
Dog/Pig Imaging/Laser $40
Dog/Pig Vitrectomy $250
Rabbit/Dog/Pig Anesthesia Inhalation $35
Rabbit/Dog/Pig Post-Op Care $15
Rabbit/Dog/Pig Euthanasia $10
Histology $40

*Rates/Fees are under review by USC Office of Financial Analysis and are subject to change.  Please contact the Core manager if you have any questions or would like additional information.

 

Vivarium Equipment

  • Heidelberg Spectralis OCT
  • Bioptigen/Leica Envisu R2210 OCT
  • Heidelberg HRT3 cornea camera
  • Zeiss surgical microscopes
  • RetCam 3 fundus camera
  • Kowa Genesis fundus camera
  • Baush and Lomb Stellaris PC vitrectomy system
  • IRIDEX OcuLight green laser
  • Synergetics Photon II laser light
  • OTI Scan ultrasound machine
  • OcuMetrics Fluorotron fluorophotometer
  • VTS digital camera
  • System Vet pulse oximeter
  • Heine digital indirect ophthalmoscope w/ camera
  • OCULUS Surgical BIOM indirect ophthalmoscope

 

Histology Services

  • Fixative preparation
  • Paraffin embedding and sectioning
  • Frozen sectioning
  • EPON resin embedding and ultrathin sectioning
  • H&E staining (paraffin and frozen sections)
  • Uranyl acetate and lead citrate staining for electron microscopy (ultrathin sections)

 

Histology Equipment

  • Leica microtomes
  • Leica processor
  • Leica embedding station
  • Leica microscope

Contact Information

Director of the Translational In Vivo Core Facility, Core Manager
Debbie Mitra, PhD
Assistant Professor of Research
USC Roski Eye Institute
Director of Science and Tech.
USC Institute for Biomedical Therapeutics
CPCB Project Manager
1450 San Pablo Street, 6th Floor
Rm 6525
Los Angeles, CA 90033
P: 323-865-0342